Textbook of Pathology Book

Description

Preface

The overwhelming success and all-round acceptance of the last edition of the textbook was very encouraging and quite stimulating but at the same time put an onerous responsibility and expectation to do better in the new edition than the best of last edition. In preparing 6th revised edition of my Textbook of Pathology, I pursued this goal with profound enthusiasm and passionate zeal. I am, thus, pleased to present to users a wholly transformed appearance and updated contents in the revised edition. While full colour printing had been introduced in the last edition 5 years back maturing the book into an international edition, the present redesigned and revised edition has utilised the contemporary technological advances in its full form in illustrations, lay-out and in printing. The revised edition has almost thrice the number of illustrations of large number of common diseases placed along with the text, and it is hoped that it will enhance understanding and learning of the subject readily, besides being a visual treat.

In recent times, advances in genetics, immunology and molecular biology have heightened our understanding of the mechanisms of diseases. As a result, mention of ‘idiopathic’ in etiology and pathogenesis of most diseases in the literature is slowly disappearing. Surely, the students of current times need to be enlightened on these modern advances in diseases; these aspects have been dealt in the revised edition with a simple and lucid approach.

Some of the Key Features of the Sixth Edition are as follows:

Thorough Textual Revision and Updating: All the chapters and topics have undergone thorough revision and updating of various aspects, including contemporary diagnostic modalities. While most of the newer information has been inserted between the lines, a few topics have been rewritten, e.g. current concepts on cell injury, immunopathology, carcinogenesis, newer infectious diseases, lymphomas-leukaemia’s, hypertension, interstitial lung diseases, etc. to name a few. In doing so, the basic accepted style of the book —simple, easy-to-understand and reproduce the subject matter, and emphasis on clarity and accuracy, has not been disturbed. Past experience has shown that the readers find tables on contrasting features and listing of salient features as a very useful medium for quick learning; considering their utility 15 new tables have been added in different chapters in the revised edition.

Reorganisation of the Book: In a departure from the conventional division of study of the subject into General and Systemic Pathology, the revised edition has been reorganised into 3 major sections—General Pathology and Basic Techniques (Chapters 1 to 11), Haematology and Lymph reticular Tissues (Chapters 12 to 14) and Systemic Pathology (Chapters 15 to 30), followed by Appendix (containing Normal Values), Further Readings for references and Index. In my considered judgement, a separate section on haematology and lymphoid tissues and redistribution of their subtopics was necessitated for two reasons—firstly, reclassification of leukaemia’s-lymphomas by the WHO as an integrated topic, making the segregation of study of diseases of ‘circulating’ and ‘tissue’ leucocytes superfluous; and secondly, due to advances in haematology, transfusion medicine and diseases of lymph reticular tissues, these subspecialties of pathology have developed a lot in recent times, requiring the students to focus on them separately for learning and they are evaluated too on these topics by separate experts. Similarly, in the revised edition, two chapters on laboratory techniques—Techniques for the Study of Pathology (Chapter 2) and Basic Diagnostic Cytology (Chapter 11) have been included in Section-I in view of technological advances in pathology which have gone beyond remaining confined as research tool but have increasingly become part of diagnostic work-up.

Profusely Illustrated: Majority of illustrations in the revised Edition are new additions while a few old ones have been done again. All the line-drawing and schematic cartoons have been updated and improved in content as well as their presentation by preparing them again on CorelDraw in soft colours, eliminating the shortcomings noticed in them in previous edition. All free-hand labelled sketches of gross specimens and line-drawings of microscopic features of an entity have been placed alongside the corresponding specimen photograph and the photomicrograph respectively, enhancing the understanding of the subject for the beginner students in pathology. In doing so, the number of figures has gone up by about three-folds in the present edition, some incorporated as an inset with focus on a close-up microscopic view.

Truly User-friendly: Rational use of various levels of headings and subheadings in different colours, bold face and in italics has been done in the text in order to highlight key points. All the citations of figures and tables in the text have been shown in colour now to make the related text vividly visible and to help user locate the same quickly on a page. It is hoped that these features will enable the user with rapid revision at the end of a topic, making the book truly user-friendly.

Much More Content but Unaltered Volume: While the new edition has a lot more updated textual material, more tables and a marked increase in the number of figures than the previous edition, a meticulous and rational page management has helped in retaining almost the same girth of the book as before.

Images and Tables on the Web: All the illustrations and tables included in this edition are being put on the website with a scratch key word on the inner page of the cover jacket. The students would find these useful for quick review and for self- assessment in which an unlabelled image (gross specimen or a photomicrograph) appears, followed by the labelled image with diagnosis corresponding to the same figure and table in the textbook. Besides, ready availability of these downloadable images and tables would be useful to fellow teachers for possibly including the same in their lectures.

Revised Pathology Quick Review and MCQs: The sixth edition of textbook is accompanied with the new revised baby-book popular with many students and interns. This small book has been found profoundly useful by the students just before practical examination to face viva voce when they need to revise huge course content in a short time, or by those preparing to take postgraduate entrance examinations. The revised edition has over 100 more new MCQs while some old ones have either been edited or replaced.

A Word on Foreword: The Foreword by Prof Ivan Damjanov, MD, PhD, from Kansas University, US, for the previous edition and now for the sixth edition so generously and meticulously prepared with an eye to the details of the book, has been most welcome development, and has helped to bring the book closer to users in other parts of the world; I express our sincere gratitude to this eminent teacher and well-known author whom I have yet to meet in person. In essence, the revised edition is a comprehensive text of pathology meant primarily for students of pathology; however, the practicing clinicians and students of other branches of medicine, dentistry, pharmacy, alternate system of medicine, and paramedical courses may also find it useful.

ACKNOWLEDGEMENTS

The revision work was indeed a mammoth task to accomplish and would not have been possible without active cooperation from friends and colleagues and continuous encouragement from well-wishers in general, and my departmental staff in particular who could bear with me for prolonged spells of my sabbatical leave. All the photomicrographs included in the present edition have been exposed afresh which has been made possible by the most valuable and selfless assistance rendered by my colleagues, Drs Shailja, Tanvi and Ujjawal, Senior Residents in Pathology, all of whom worked tirelessly for endless hours for months, much to the sacrifice of their personal comfort and time of their families, for which I am indebted to them. Here, I also recall the help accorded by my former students and colleagues in preparation of earlier editions of the book and thank once again, even though much of that may have been replaced. As always, I remain indebted to those from whom I had the opportunity to learn pathology; in particular to Prof K Joshi, MD, PhD, PGIMER, Chandigarh, Late Prof TS Jaswal, MD, and Prof Uma Singh, MD, formerly at PGIMS, Rohtak.

Constant strategic support and encouragement extended by the Department of Medical Education and Research, Chandigarh Administration, during the completion of work is gratefully acknowledged.

I may have been hard-task master and highly demanding on quality and accuracy from all staff members of the M/s Jaypee Brothers Medical Publishers (P) Ltd, at times losing my patience, but all of them have been very cooperative and quite accommodating. In particular, I would like to thank profusely Mr Manoj Pahuja, Computer Art Designer, for carrying out Herculean job on figures as per my requirements conscientiously and patiently with competence; Mrs Y Kapoor, Senior Desktop Operator, for overall lay-out of the book and acceding to all my requests for amendments smilingly and ungrudgingly till the very last minute; and Ms Chetna Malhotra, MBA, Senior Business Development Manager, for overseeing the entire project vigilantly and efficiently. All through this period, Mr Tarun Duneja, (Director-Publishing), M/s Jaypee Brothers Medical Publishers (P) Ltd, has been highly cooperative and supportive.

Lastly, the vision of Shri JP Vij, Chairman and Managing Director of M/s Jaypee Brothers Medical Publishers (P) Ltd, has been to see the revised edition as unmatched internationally and keeping it affordable at the same time, much above his business interests, and I do hope his dream comes true. Full credit goes to M/s Ajanta Printers, Faridabad, for the admirably high quality of printing.

Finally, the users of previous editions are gratefully acknowledged for having brought this textbook at this pedestal. In the past, I have gained profitably by suggestions from colleagues and students and I urge them to continue giving their valuable suggestions and point out errors, if any, so that I may continue to improve it.

Government Medical College

Harsh Mohan,

MD, MNAMS, FICPath, FUICC

Professor & Head Department of Pathology

Content

• Section I
  • GENERAL PATHOLOGY AND BASIC TECHNIQUES
    • CHAPTER 1 Introduction to Pathology
    • CHAPTER 1 Introduction to Pathology
    • CHAPTER 3 Cell Injury and Cellular Adaptations
    • CHAPTER 4 Immunopathology Including Amyloidosis
    • CHAPTER 5 Derangements of Homeostasis and 93 Haemodynamics
    • CHAPTER 6 Inflammation and Healing
    • CHAPTER 7 Infectious and Parasitic Diseases
    • CHAPTER 8 Neoplasia
    • CHAPTER 9 Environmental and Nutritional Diseases
    • CHAPTER 10 Genetic and Paediatric Diseases
    • CHAPTER 11 Basic Diagnostic Cytology
• Section II
  • HAEMATOLOGY AND LYMPHORETICULAR TISSUES
    • CHAPTER 12 Introduction to Haematopoietic System and Disorders of Erythroid Series
    • CHAPTER 13 Disorders of Platelets, Bleeding Disorders and Basic Transfusion Medicine
    • CHAPTER 14 Disorders of Leucocytes and Lymphoreticular Tissues
• Section III
  • SYSTEMIC PATHOLOGY
    • CHAPTER 15 The Blood Vessels and Lymphatics
    • CHAPTER 16 The Heart
    • CHAPTER 17 The Respiratory System
    • CHAPTER 18 The Eye, ENT and Neck
    • CHAPTER 19 The Oral Cavity and Salivary Glands
    • CHAPTER 20 The Gastrointestinal Tract
    • CHAPTER 21 The Liver, Biliary Tract and Exocrine Pancreas
    • CHAPTER 22 The Kidney and Lower Urinary Tract
    • CHAPTER 23 The Male Reproductive System and Prostate
    • CHAPTER 24 The Female Genital Tract
    • CHAPTER 25 The Breast
    • CHAPTER 26 The Skin
    • CHAPTER 27 The Endocrine System
    • CHAPTER 28 The Musculoskeletal System
    • CHAPTER 29 Soft Tissue Tumours
    • CHAPTER 30 The Nervous System
• APPENDIX Normal Values