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Genetic Engineering & Applications Lecture Note

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Name of Notes : – Genetic Engineering & Applications Lecture Note

Introduction

Gene targeting is a different technique that uses homologous recombination to change an endogenous gene, and can be used to delete a gene, remove exons, add a gene, or introduce point mutations. Genetic engineering has applications in medicine, research, industry and agriculture and can be used on a wide range of plants, animals and microorganisms.

Genetic engineering has produced a variety of drugs and hormones for medical use. For example, one of its earliest uses in pharmaceuticals was gene splicing to manufacture large amounts of insulin, made using cells of E. coli bacteria. Interferon, which is used to eliminate certain viruses and kill cancer cells, also is a product of genetic engineering, as are tissue plasminogen activator and urokinase, which are used to dissolve blood clots.

Another byproduct is a type of human growth hormone; it’s used to treat dwarfism and is produced through genetically-engineered bacteria and yeasts. The evolving field of gene therapy involves manipulating human genes to treat or cure genetic diseases and disorders. Modified plasmids or viruses often are the messengers to deliver genetic material to the body’s cells, resulting in the production of substances that should correct the illness. Sometimes cells are genetically altered inside the body; other times scientists modify them in the laboratory and return them to the patient’s body.

Since the 1990s, gene therapy has been used in clinical trials to treat diseases and conditions such as AIDS, cystic fibrosis, cancer, and high cholesterol. Drawbacks of gene therapy are that sometimes the person’s immune system destroys the cells that have been genetically altered, and also that it is hard to get the genetic material into enough cells to have the desired effect.

Modules / Lectures

  • Introduction
  • Enzymes In Genetic Engineering
  • Nucleic Acid Hybridization And Amplification
  • Construction Of DNA Libraries
  • Gene Transfer Techniques
  • Transgenic Science And Genetic Improvement
  • Other Applications
  • Gene Therapy

Additional information

Product Name

Genetic Engineering & Applications Lecture Note

Product Size

10.2 MB

Format

File Format

File Category

DEPARTMENT/COURSE

Need For

College, Competition, Entrance, Exams, PSU, Semester, University

Product Type

Written By

Dr. Utpal Bora

Provided By

IIT Guwahati

Uploaded By

Roop Chandra

Languages

English

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